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Cell Stem Cell. 2012 May 4;10(5):497-503. doi: 10.1016/j.stem.2012.04.011.

NuRD and pluripotency: a complex balancing act.

Author information

1
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. hug4@niehs.nih.gov

Abstract

Embryonic stem cells (ESCs) are defined by two essential features--pluripotency and self-renewal--whose balance requires the concerted action of signal transduction pathways, transcription factor networks, and epigenetic regulators. Recent findings have implicated the NuRD chromatin remodeling complex in the sophisticated choreography of ESC regulatory pathways.

PMID:
22560073
PMCID:
PMC3348611
DOI:
10.1016/j.stem.2012.04.011
[Indexed for MEDLINE]
Free PMC Article

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