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Cell Stem Cell. 2012 May 4;10(5):484-5. doi: 10.1016/j.stem.2012.04.016.

Grounded: transcriptional pausing in naive mESCs.

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1
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Growing mouse pluripotent stem cells in defined media with signaling inhibitors establishes a naive ground state different from that of cells grown in serum. Recently in Cell, Marks et al. (2012) reported differences in the transcriptional and epigenomic landscapes of naive and serum-exposed mouse stem cells that improve our understanding of the pluripotent ground state.

PMID:
22560069
DOI:
10.1016/j.stem.2012.04.016
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