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Curr Opin Immunol. 2012 Aug;24(4):476-81. doi: 10.1016/j.coi.2012.04.001. Epub 2012 May 1.

Properties of end-stage human T cells defined by CD45RA re-expression.

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1
Division of Infection and Immunity, University College London, 5 University Street, London, WC1E 6JF, UK. s.henson@ucl.ac.uk

Abstract

Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation of highly differentiated CD45RA re-expressing memory T cells. These cells increase during ageing, especially in individuals who are infected with cytomegalovirus (CMV). These cells have decreased proliferative capacity, increased activation of senescence signalling pathways and greater susceptibility to apoptosis in vitro. However these cells are capable of multiple effector functions and thus bear all the hallmarks of short-lived effector T cells. This indicates that senescence signalling may govern the unique characteristics of effector T cells. In this article, we address the functional and migratory properties of these T cells and mechanisms that are involved in their generation. Finally we assess the potential for manipulation of their activity and whether this may improve immune function during ageing.

PMID:
22554789
DOI:
10.1016/j.coi.2012.04.001
[Indexed for MEDLINE]
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