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Cold Spring Harb Perspect Med. 2012 May;2(5):a011668. doi: 10.1101/cshperspect.a011668.

Iron metabolism: interactions with normal and disordered erythropoiesis.

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1
Department of Medicine and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. tganz@mednet.ucla.edu

Abstract

Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.

PMID:
22553501
PMCID:
PMC3331689
DOI:
10.1101/cshperspect.a011668
[Indexed for MEDLINE]
Free PMC Article
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