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Nucleic Acids Res. 2012 Jul;40(Web Server issue):W222-7. doi: 10.1093/nar/gks363. Epub 2012 May 2.

MOLEonline 2.0: interactive web-based analysis of biomacromolecular channels.

Author information

1
Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University Olomouc, tr. 17. listopadu 12, 771 46 Olomouc, Czech Republic.

Abstract

Biomolecular channels play important roles in many biological systems, e.g. enzymes, ribosomes and ion channels. This article introduces a web-based interactive MOLEonline 2.0 application for the analysis of access/egress paths to interior molecular voids. MOLEonline 2.0 enables platform-independent, easy-to-use and interactive analyses of (bio)macromolecular channels, tunnels and pores. Results are presented in a clear manner, making their interpretation easy. For each channel, MOLEonline displays a 3D graphical representation of the channel, its profile accompanied by a list of lining residues and also its basic physicochemical properties. The users can tune advanced parameters when performing a channel search to direct the search according to their needs. The MOLEonline 2.0 application is freely available via the Internet at http://ncbr.muni.cz/mole or http://mole.upol.cz.

PMID:
22553366
PMCID:
PMC3394309
DOI:
10.1093/nar/gks363
[Indexed for MEDLINE]
Free PMC Article

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