A) The peak, phase-locked, cortical firing rates (FR) for all presynaptic firing rates. Peak FR significantly differed between 2 Hz (solid circles) and 8 Hz modulations (open circles, ** p<0.01, paired t-test). The relationship between peak FR and presynaptic FR was linear in the 8 Hz case (R>0.85) but saturating in the 2 Hz case (exponential fit, X^{2}: 0.12–0.29). This was true for all synapse types: A1) F-synapses, red, A2) FD-synapses, green, A3) D-synapses, blue. B1) In both the 2 Hz (left) and 8 Hz (right) cases, F-synapses drove cortical responses with higher peak FRs than FD- or D-synapses (** p<0.01, paired t-test). B2) The range of peak cortical FR was greatest for F-synapses during 2 Hz rhythms and for F and FD-synapses during 8 Hz rhythms (F red bars, FD green bars; D, blue bars; * p<0.05, ** p<0.01, paired t-test; Range = cortical FR for the highest presynaptic FR minus the cortical FR for the lowest presynaptic FR). C) The mean FRs increased with presynaptic rate but did not differ for 2 Hz (solid circles) versus 8 Hz (open circles) modulations, C1) F-synapses, C2) FD-synapses, C3) D-synapses. D1) In both the 2 Hz (left) and 8 Hz (right) cases, F and FD synapses drove cortical responses with higher mean FRs than D-synapses (** p<0.01, paired t-test). D2) The range of mean cortical FRs was greatest for facilitation-dominant synapses (F, red bars, **, p<0.01, paired t-test, see also ). For all synapse types, the range of mean firing rates did not significantly (n.s.) differ between the 2 Hz and 8 Hz cases. Error bars: ± SE.

## PubMed Commons