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Nat Cell Biol. 2012 May 2;14(5):448-50. doi: 10.1038/ncb2494.

DNA breakage drives nuclear search.

Author information

1
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. gira@bcm.edu

Abstract

The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.

PMID:
22552144
PMCID:
PMC4495951
DOI:
10.1038/ncb2494
[Indexed for MEDLINE]
Free PMC Article
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