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J Ethnopharmacol. 1990 Sep;30(2):205-14.

A hypotensive procyanidin-glycoside from Rhamnus lycioides ssp. lycioides.

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Departamento de Farmacología y Farmacotecnia, Facultad de Farmacia, Universitat de València, Spain.


A lyophilized hot water extract of the aerial parts of Rhamnus lycioides L. (Rhamnaceae) produced a lowering of systemic arterial blood pressure in normotensive anaesthetized Wistar rats. An activity-guided fractionation of the methanolic extract led to the isolation of a tetrameric procyanidin-glycoside which produced a clear dose-dependent hypotensive response (1.5-6 mg/kg i.v.). This principle was characterized using acid hydrolysis, thiolytic degradation and spectroscopic methods. It consisted of four flavanol units with a 2,3-cis configuration and with a O-beta-d-glucosylpyranoside function on the epicatechin terminal unit. The interflavan linkage was (4-8).

[Indexed for MEDLINE]

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