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Proc Am Thorac Soc. 2012 May;9(2):62-3. doi: 10.1513/pats.201201-012MS.

Senescence in chronic obstructive pulmonary disease.

Author information

1
Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA. Rubin.Tuder@ucdenver.edu

Abstract

There is a growing realization that chronic obstructive pulmonary disease involves several processes present in aging and cellular senescence. The impact of these processes in the pathogenesis of the main manifestations is multiple, particularly in the propagation of a proinflammatory phenotype, loss of reparative potential, and amplification of oxidative stress, all ultimately leading to tissue damage. This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung Conference.

PMID:
22550244
PMCID:
PMC3359109
DOI:
10.1513/pats.201201-012MS
[Indexed for MEDLINE]
Free PMC Article

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