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Cold Spring Harb Perspect Biol. 2012 May 1;4(5). pii: a008300. doi: 10.1101/cshperspect.a008300.

Mammalian kidney development: principles, progress, and projections.

Author information

1
Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia. M.Little@imb.uq.edu.au

Abstract

The mammalian kidney is a vital organ with considerable cellular complexity and functional diversity. Kidney development is notable for requiring distinct but coincident tubulogenic processes involving reciprocal inductive signals between mesenchymal and epithelial progenitor compartments. Key molecular pathways mediating these interactions have been identified. Further, advances in the analysis of gene expression and gene activity, coupled with a detailed knowledge of cell origins, are enhancing our understanding of kidney morphogenesis and unraveling the normal processes of postnatal repair and identifying disease-causing mechanisms. This article focuses on recent insights into central regulatory processes governing organ assembly and renal disease, and predicts future directions for the field.

PMID:
22550230
PMCID:
PMC3331696
DOI:
10.1101/cshperspect.a008300
[Indexed for MEDLINE]
Free PMC Article

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