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Genes Dev. 2012 May 15;26(10):1022-7. doi: 10.1101/gad.189514.112. Epub 2012 May 1.

PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis.

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1
Institut de Biologie moléculaire des plantes du CNRS, University of Strasbourg, 67084 Strasbourg, France.

Abstract

RNase P is an essential enzyme that cleaves the 5' leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity. Here we find that protein-only RNase P enzymes called PRORP (for proteinaceous RNase P) support RNase P activity in vivo in both organelles and the nucleus in Arabidopsis. Beyond tRNA, PRORP proteins are involved in the maturation of small nucleolar RNA (snoRNA) and mRNA. Finally, ribonucleoprotein RNase MRP is not involved in tRNA maturation in plants. Altogether, our results indicate that ribonucleoprotein enzymes have been entirely replaced by proteins for RNase P activity in plants.

PMID:
22549728
PMCID:
PMC3360558
DOI:
10.1101/gad.189514.112
[Indexed for MEDLINE]
Free PMC Article
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