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Pediatr Infect Dis J. 2012 Sep;31(9):920-3. doi: 10.1097/INF.0b013e31825aff25.

Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing.

Author information

1
Seinäjoki Central Hospital, Seinäjoki, Finland. kirsi.nuolivirta@ fimnet.fi

Abstract

BACKGROUND:

Innate immunity receptors play a critical role in host defense. In addition, the expression of Toll-like receptors (TLRs) has been connected to allergy and asthma.

AIMS:

: To evaluate the association between the TLR3 L412F polymorphism and viral findings, clinical characteristics and subsequent wheezing in young infants with bronchiolitis.

METHODS:

In all, 129 full-term infants hospitalized for bronchiolitis at age <6 months have been followed-up until the mean age of 1.5 years. Genotyping of the TLR3 L412F gene mutation was made by pyrosequencing.

RESULTS:

TLR3 L412F gene polymorphism including the minor allele T was overrepresented (52%) in infants hospitalized with bronchiolitis. The presence of the major allele C as homozygous was associated with repeated postbronchiolitis wheezing (7.06, 95% confidence interval 2.30-21.66).

CONCLUSION:

Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.

PMID:
22549436
DOI:
10.1097/INF.0b013e31825aff25
[Indexed for MEDLINE]
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