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Biochim Biophys Acta. 2013 Jan;1833(1):184-94. doi: 10.1016/j.bbamcr.2012.04.007. Epub 2012 Apr 21.

The meaning of mitochondrial movement to a neuron's life.

Author information

1
Department of Neurosurgery, Stanford University School of Medicine, USA. lovas@stanford.edu

Abstract

Cells precisely regulate mitochondrial movement in order to balance energy needs and avoid cell death. Neurons are particularly susceptible to disturbance of mitochondrial motility and distribution due to their highly extended structures and specialized function. Regulation of mitochondrial motility plays a vital role in neuronal health and death. Here we review the current understanding of regulatory mechanisms that govern neuronal mitochondrial transport and probe their implication in health and disease. This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology.

PMID:
22548961
PMCID:
PMC3413748
DOI:
10.1016/j.bbamcr.2012.04.007
[Indexed for MEDLINE]
Free PMC Article
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