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Allergy Asthma Immunol Res. 2012 May;4(3):161-4. doi: 10.4168/aair.2012.4.3.161. Epub 2011 Dec 28.

A case of hypereosinophilic syndrome presenting with multiorgan infarctions associated with disseminated intravascular coagulation.

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Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


Thromboembolism is one of the most critical complications of hypereosinophilic syndrome (HES). We report here a case of multi-organ infarctions related to HES. A 23-year-old woman was referred to our hospital with hemoptysis. Not only pulmonary, but also renal and splenic infarctions were detected on computed tomography images. Blood tests showed profound peripheral eosinophilia. She was diagnosed with HES with disseminated intravascular coagulation (DIC). We initiated infusion of corticosteroids, which effectively suppressed peripheral eosinophilia. However, consumptive coagulopathy did not improve and intracerebral hemorrhage related to thrombosis then developed. Addition of interferon-alpha resulted in the correction of the DIC associated with HES.


Hypereosinophilic syndrome; consumptive coagulopathy; disseminated intravascular coagulation; eosinophilia; interferon-alpha; thromboembolism

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