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Int J Rheumatol. 2012;2012:860213. doi: 10.1155/2012/860213. Epub 2012 Apr 4.

Prevalence of HLA-B27 in Patients with Ankylosing Spondylitis in Qatar.

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1
Rheumatology Section, Department of Medicine, Hamad General Hospital, P.O. Box 3050, Doha, Qatar.

Abstract

BACKGROUND AND OBJECTIVES:

The human leukocyte antigen HLA-B27 is a class 1 antigen of the major histocompatibility complex and is strongly associated with ankylosing spondylitis (AS). The purpose of the present study is to investigate the distribution of HLA-B27 in patients with AS of different ethnic groups in Qatar.

DESIGN AND SETTING:

Study design was cross-sectional and the setting was rheumatology clinics of Hamad General Hospital in Qatar where most of ankylosing spondylitis patients are followed up.

PATIENTS AND METHODS:

Patients with diagnosis of AS who met the New York modified criteria for AS were tested for HLA-B27. 119 patients were tested for HLA-B27: 66 Arabs, 52 Asians (Indians, Pakistanis, Bengalis, and Iranians), and one Western (Irish).

RESULTS:

Of all the individuals, 82 were positive (69%) for HLA-B27. Among the Arabs, 49/66 were positive (74%). Among the Asians, 32/52 were positive (61%). Furthermore, Qatari patients (10 males and one female) 9 were positive (82%), 14/19 Jordanians/Palestinians were positive, and 9/10 (90%) Egyptians were positive. Among the Asians, 19/26 Indians were positive (73%), which was similar to the Arabs.

CONCLUSION:

HLA-B27 in our small group of Arabs is present in 74%. Comparison with other data will be presented in detail.

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