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AIDS. 2012 Aug 24;26(13):1691-705.

The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study.

Collaborators (1193)

Ainsworth J, Anderson J, Babiker A, Chadwick D, Delpech V, Dunn D, Fisher M, Gazzard B, Gilson R, Gompels M, Hill T, Johnson M, Leen C, Nelson M, Orkin C, Palfreeman A, Phillips A, Pillay D, Post F, Sachikonye M, Schwenk A, Walsh J, Huntington S, Phillips A, Glabay A, Garrett N, Lynch J, Hand J, de Souza C, Fisher M, Perry N, Tilbury S, Churchill D, Gazzard B, Nelson M, Waxman M, Asboe D, Mandalia S, Delpech V, Anderson J, Munshi S, Korat H, Taylor C, Gleisner Z, Ibrahim F, Campbell L, Gilson R, Brima N, Williams I, Schwenk A, Ainsworth J, Wood C, Miller S, Johnson M, Youle M, Lampe F, Smith C, Grabowska H, Chaloner C, Weber J, Ramzan F, Mackie N, Winston A, Leen C, Wilson A, Gompels M, Allan S, Palfreeman A, Moore A, Chadwick D, Wakeman K, Bezemer DO, Gras LA, Kesselring AM, van Sighem AI, Smit C, Zhang S, Zaheri S, Prins JM, Boer K, Bos JC, Geerlings SE, Godfried MH, Haverkort ME, Kuijpers TW, Lange JM, van der Meer JT, Nellen FJ, Pajkrt D, van der Poll T, Reiss P, Scherpbier HJ, van der Valk M, Vrouenraets SM, van Vugt M, Wit FW, Schreij G, Lowe S, Oude Lashof A, Bravenboer B, Pronk MJ, van der Ende ME, van der Feltz M, Gelinck LB, Nouwen JL, Rijnders BJ, de Ruiter ED, Slobbe L, Schurink CA, Verbon A, de Vries-Sluijs TE, Driessen G, Hartwig NG, Branger J, Kauffmann RH, Schippers EF, Groeneveld PH, Alleman MA, Bouwhuis JW, Kroon FP, Arend SM, de Boer MG, van den Broek PJ, van Dissel JT, Jolink H, van Nieuwkoop C, den Hollander JG, Pogany K, Bronsveld W, Kortmann W, van Twillert G, Vriesendorp R, Leyten EM, van Houte D, Polée MB, van Vonderen MG, ten Napel CH, Kootstra GJ, Brinkman K, van den Berk GE, Blok WL, Frissen PH, Schouten WE, van Eeden A, Verhagen DW, Mulder JW, van Gorp EC, Smit PM, Weijer S, Juttmann JR, Brouwer AE, van Kasteren ME, Veenstra J, Lettinga KD, Koopmans PP, Brouwer AM, Dofferhoff AS, van der Flier M, de Groot R, ter Hofstede HJ, Keuter M, van der Ven AJ, Sprenger HG, van Assen S, Doedens R, Scholvinck EH, Stek CJ, Hoepelman AI, Arends JE, Ellerbroek PM, van der Hilst JC, Jaspers CA, Maarschalk-Ellerbroek LJ, Oosterheert JJ, Peters EJ, Mudrikova T, Schneider MM, Wassenberg MW, Geelen SP, Wolfs TF, Danner SA, van Agtmael MA, Bierman WF, Claessen FA, de Jong EV, Kortmann W, Perenboom RM, bij de Vaate EA, Richter C, van der Berg J, Gisolf EH, van den Berge M, Stegeman A, Duits AJ, Winkel K, Barin F, Bentata M, Billaud E, Boué F, Burty C, Cabié A, Cotte L, De Truchis P, Duval X, Duvivier C, Enel P, Fredouille-Heripret L, Gasnault J, Gaud C, Gilquin J, Grabar S, Katlama C, Khuong MA, Lang JM, Lascaux AS, Launay O, Mahamat A, Mary-Krause M, Matheron S, Meynard JL, Pavie J, Pialoux G, Pilorgé F, Poizot-Martin I, Pradier C, Reynes J, Rouveix E, Simon A, Tattevin P, Tissot-Dupont H, Viard JP, Viget N, Salomon V, Jacquemet N, Guiguet M, Lanoy E, Lièvre L, Selinger-Leneman H, Lacombe JM, Potard V, Bricaire F, Herson S, Katlama C, Simon A, Desplanque N, Girard PM, Meynard JL, Meyohas MC, Picard O, Cadranel J, Mayaud C, Pialoux G, Clauvel JP, Decazes JM, Gerard L, Molina JM, Diemer M, Sellier P, Bentata M, Honoré P, Jeantils V, Tassi S, Mechali D, Taverne B, Bouvet E, Crickx B, Ecobichon JL, Matheron S, Picard-Dahan C, Yeni P, Berthé H, Dupont C, Chandemerle C, Mortier E, de Truchis P, Tisne-Dessus D, Weiss L, Salmon D, Auperin I, Gilquin J, Roudière L, Viard JP, Fior R, Delfraissy JF, Goujard C, Jung C, Lesprit PH, Vittecoq D, Fraisse P, Lang JM, Rey D, Beck-Wirth G, Stahl JP, Lecercq P, Gourdon F, Laurichesse H, Fresard A, Lucht F, Bazin C, Verdon R, Chavanet P, Arvieux C, Michelet C, Choutet P, Goudeau A, Maître MF, Hoen B, Eglinger P, Faller JP, Borsa-Lebas F, Caron F, Reynes J, Daures JP, May T, Rabaud C, Berger JL, Rémy G, Arlet-Suau E, Cuzin L, Massip P, Thiercelin Legrand MF, Pontonnier G, Viget N, Yasdanpanah Y, Dellamonica P, Pradier C, Pugliese P, Aleksandrowicz K, Quinsat D, Ravaux I, Tissot-Dupont H, Delmont JP, Moreau J, Gastaut JA, Poizot-Martin I, Retornaz F, Soubeyrand J, Galinier A, Ruiz JM, Allegre T, Blanc PA, Bonnet-Montchardon D, Lepeu G, Esterni JP, Granet-Brunello P, Pelissier L, Cohen-Valensi R, Nezri M, Chadapaud S, Laffeuillade A, Billaud E, Raffi F, Boibieux A, Peyramond D, Livrozet JM, Touraine JL, Cotte L, Trepo C, Strobel M, Bissuel F, Pradinaud R, Sobesky M, Cabié A, Gaud C, Contant M, Aebi C, Battegay M, Bernasconi E, Böni J, Bucher HC, Bürgisser P, Brazzola P, Cheseaux JJ, Drack G, Calmy A, Cattacin S, Cavassini M, Dubs R, Egger M, Fischer M, Flepp M, Fontana A, Francioli P, Furrer HJ, Gyr T, Fux C, Gayet-Ageron A, Gerber S, Gorgievski M, Günthard H, Hirsch H, Hirschel B, Hösli I, Kahlert Ch, Hüsler M, Kaiser L, Ledergerber B, Martinetti G, Martinez B, Müller N, Nadal D, Paccaud F, Pantaleo G, Raio L, Rauch A, Regenass S, Rickenbach M, Rudin C, Schmid P, Schultze D, Schüpbach J, Speck R, Taffé P, Telenti A, Trkola A, Vernazza P, Weber R, Wyler CA, Yerly S, Miró JM, Gallois A, Podzamczer D, Murillas J, Gatell JM, Manzardo C, Tural C, Clotet B, Ferrer E, Riera M, Segura F, Navarro G, Force L, Vilaró J, Masabeu A, García I, Guadarrama M, Cifuentes C, Dalmau D, Jaen À, Agustí C, Montoliu A, Pérez I, Gargoulas F, Blanco JL, Garcia-Alcaide F, Martínez E, Mallolas J, López-Dieguez M, García-Goez JF, Sirera G, Romeu J, Jou A, Negredo E, Miranda C, Capitan MC, Saumoy M, Imaz A, Tiraboschi JM, Murillo O, Bolao F, Peña C, Cabellos C, Masó M, Vila A, Sala M, Cervantes M, Amengual MJ, Navarro M, Penelo E, Barrufet P, Bejarano G, Molina J, Guadarrama M, Alvaro M, Mercadal J, Fernández J, Ospina JE, Berenguer J, García F, Gutiérrez F, Labarga P, Caro-Murillo AM, Muñoz MA, Sobrino P, Jarrín I, Gómez Sirvent JL, Rodríguez P, Alonso MM, López AM, Hernández MI, Soriano V, Labarga P, Barreiro P, Medrano J, Rivas P, Herrero D, Blanco F, Vispo ME, Martín L, Ramírez G, de Diego M, Rubio R, Pulido F, Moreno V, Cepeda C, Hervás R, Iribarren JA, Arrizabalaga J, Aramburu MJ, Camino X, Rodríguez-Arrondo F, von Wichmann MA, Pascual L, Goenaga MA, Gutiérrez F, Masiá M, Ramos JM, Padilla S, Sánchez-Hellín V, Bernal E, Escolano C, Montolio F, Peral Y, Berenguer J, López JC, Miralles P, Cosín J, Sánchez M, Gutiérrez I, Ramírez M, Padilla B, Vidal F, Sanjuan M, Peraire J, Veloso S, Viladés C, López-Dupla M, Olona M, Vargas M, Aldeguer JL, Blanes M, Lacruz J, Salavert M, Montero M, Cuéllar S, de los Santos I, Sanz J, Oteo JA, Blanco JR, Ibarra V, Metola L, Sanz M, Pérez-Martínez L, Sola J, Uriz J, Castiello J, Reparaz J, Arriaza MJ, Irigoyen C, Antela A, Casado JL, Dronda F, Moreno A, Pérez MJ, López D, Gutiérrez C, Hernández B, Pumares M, Martí P, García L, Page C, García F, Hernández J, Peña A, Muñoz L, Parra J, Viciana P, Leal M, López-Cortés LF, Trastoy M, Mata R, Bryant K, Braithwaite S, Crothers K, Fiellin DA, Freiberg M, LoRe V, Rimland D, Guest J, Oursler KA, Titanji R, Brown S, Garrison S, Rodriguez-Barradas M, Masozera N, Goetz M, Leaf D, Simberkoff M, Blumenthal D, Leaf H, Leung J, Butt A, Hoffman E, Gibert C, Peck R, Brandt C, Dubrow R, Gandhi N, Lim J, McGinnis K, Parikh C, Tate J, Wang E, Womack J, Babiker A, Brettle R, Darbyshire J, Delpech V, Easterbrook P, Fidler S, Fisher M, Gilson R, Goldberg D, Hawkins D, Jaffe H, Johnson A, Johnson M, McLean K, Pillay D, Porter K, Cursley A, Ewings F, Fairbrother K, Gnatiuc L, Murphy B, Douglas G, Kennedy N, Pritchard J, Andrady U, Rajda N, Maw R, McKernan S, Drake S, Gilleran G, White D, Ross J, Toomer S, Hewart R, Wilding H, Woodward R, Dean G, Heald L, Horner P, Glover S, Bansaal D, Eduards S, Carne C, Browing M, Das R, Stanley B, Estreich S, Magdy A, O'Mahony C, Fraser P, Hayman B, Jebakumar SP, Joshi U, Ralph S, Wade A, Mette R, Lalik J, Summerfield H, El-Dalil A, France AJ, White C, Robertson R, Gordon S, McMillan S, Lean C, Morris S, Vithayathil K, McLean L, Winter A, Gale D, Jacobs S, Tayal S, Short L, Roberts M, Green S, Williams G, Sivakumar K, Bhattacharyya DN, Monteiro E, Minton J, Dhar J, Nye F, DeSouza CB, Isaksen A, McDonald L, McLean K, Franca A, Hawkins D, William L, Jendrulek I, Peters B, Shaunak S, El-Gadi S, Easterbrook PJ, Mazhude C, Gilson R, Johnstone R, Fakoya A, Mchale J, Waters A, Kegg S, Mitchell S, Byrne P, Johnson M, Rice P, Fidler S, Mullaney SA, McCormack S, David D, Melville R, Phillip K, Balachandran T, Mabey-Puttock S, Sukthankar A, Murphy C, Wilkins E, Ahmad S, Tayal S, Haynes J, Evans E, Ong E, Das R, Grey R, Meaden J, Bignell C, Loay D, Peacock K, Girgis MR, Morgan B, Palfreeman A, Wilcox J, Tobin J, Tucker L, Saeed AM, Chen F, Deheragada A, Williams O, Lacey H, Herman S, Kinghorn D, Devendra SV, Wither J, Dawson S, Rowen D, Harvey J, Wilkins E, Bridgwood A, Singh G, Chauhan M, Kellock D, Young S, Dannino S, Kathir Y, Rooney G, Currie J, Fitzgerald M, Devendra S, Keane F, Booth G, Green T, Arumainayyagam J, Chandramani S, Rajamanoharan S, Robinson T, Curless E, Gokhale R, Tariq A, Roberts M, Williams O, Luzzi G, FitzGerald M, Fairley I, Wallis F, Smit E, Ward F, Molina JM, Loze B, Morlat P, Bonarek M, Bonnet F, Nouts C, Louis I, Raffi F, Reliquet V, Sauser F, Biron C, Mounoury O, Hue H, Brosseau D, Delfraissy JF, Goujard C, Ghosn J, Rannou MT, Bergmann JF, Badsi E, Rami A, Diemer M, Parrinello M, Samanon-Bollens D, Campa P, Tourneur M, Desplanques N, Livrozet JM, Jeanblanc F, Chiarello P, Makhloufi D, Blanc AP, Allègre T, Reynes J, Baillat V, Lemoing V, Merle de Boever C, Tramoni C, Cabié A, Sobesky G, Abel S, Beaujolais V, Pialoux G, Slama L, Chakvetadze C, Berrebi V, Yeni P, Bouvet E, Fournier I, Gerbe J, Trepo C, Koffi K, Augustin-Normand C, Miailhes P, Thoirain V, Brochier C, Thomas R, Souala F, Ratajczak M, Beytoux J, Jacomet C, Gourdon F, Rouveix E, Morelon S, Dupont C, Olivier C, Lortholary O, Dupont B, Viard JP, Maignan A, Ragnaud JM, Raymond I, Leport C, Jadand C, Jestin C, Longuet P, Boucherit S, Sereni D, Lascoux C, Prevoteau F, Sobel A, Levy Y, Lelièvre JD, Dominguez S, Dumont C, Aumaître H, Delmas B, Saada M, Medus M, Guillevin L, Salmon D, Tahi T, Yazdanpanah Y, Pavel S, Marien MC, Drenou B, Beck-Wirth G, Beck C, Benomar M, Katlama C, Tubiana R, Ait Mohand H, Chermak A, Ben Abdallah S, Bentata M, Touam F, Hoen B, Drobacheff C, Folzer A, Massip P, Obadia M, Prudhomme L, Bonnet E, Balzarin F, Pichard E, Chennebault JM, Fialaire P, Loison J, Galanaud P, Bornarel D, Six M, Ferret P, Weiss L, Batisse D, Gonzales-Canali G, Tisne-Dessus D, Devidas A, Chevojon P, Turpault I, Lafeuillade A, Cheret A, Philip G, Morel P, Timsit J, Herson S, Amirat N, Simon A, Brancion C, Cabane J, Picard O, Tredup J, Desplanques N, Stein A, Ravault I, Chavanet C, Buisson M, Treuvetot S, Choutet P, Nau P, Bastides F, Boyer L, Wassoumbou S, Oksenhendeler E, Gérard L, Bernard L, De Truchis P, Berthé H, Domart Y, Merrien D, Greder Belan A, Gayraud M, Bodard L, Meudec A, Beuscart C, Daniel C, Pape E, Vinceneux P, Simonpoli AM, Zeng A, Fournier L, Fuzibet JG, Sohn C, Rosenthal E, Quaranta M, Dellamonica P, Chaillou S, Sabah M, Audhuy B, Schieber A, Moreau P, Niault M, Vaillant O, Huchon G, Compagnucci A, De Lacroix Szmania I, Richier L, Lamaury I, Saint-Dizier F, Garipuy D, Gastaut JA, Drogoul MP, Poizot Martin I, Fabre G, Lambert de Cursay G, Abraham B, Perino C, Lagarde P, David F, Roche-Sicot J, Saraux JL, Leprêtre A, Fampin B, Uludag A, Morin AS, Bletry O, Zucman D, Regnier A, Girard JJ, Quinsat DT, Heripret L, Grihon F, Houlbert D, Ruel M, Chemlal K, Caron F, Debab Y, Tremollieres F, Perronne V, Slama B, Perré P, Miodovski C, Guermonprez G, Dulioust A, Boudon P, Malbec D, Patey O, Semaille C, Deville J, Remy G, Béguinot I, Boue F, Chambrin V, Pignon C, Estocq GA, Levy A, Delfraissy JF, Goujard C, Duracinsky M, Le Bras P, Ngussan MS, Peretti D, Medintzeff N, Lambert T, Segeral O, Lezeau P, Laurian Y, Weiss L, Buisson M, Piketty C, Karmochkine M, Batisse D, Eliaszewitch M, Jayle D, Tisne-Dessus D, Kazatchkine M, Leport C, Colasante U, Jadand C, Jestin C, Duval X, Nouaouia W, Boucherit S, Vilde JL, Bollens D, Binet D, Diallo B, Meyohas MC, Fonquernie L, Lagneau JL, Salmon D, Guillevin L, Tahi T, Launay O, Pietrie MP, Sicard D, Stieltjes N, Michot J, Sobel A, Levy Y, Bourdillon F, Lelievre JD, Dumont C, Dupont B, Obenga G, Viard JP, Maignan A, Escaut L, Bolliot C, Bricaire F, Katlama C, Schneider L, Herson S, Simon A, Iguertsira M, Stein A, Tomei C, Ravaux I, Dhiver C, Tissot Dupont H, Vallon A, Gallais J, Gallais H, Gastaut JA, Drogoul MP, Fabre G, Dellamonica P, Durant J, Mondain V, Perbost I, Cassuto JP, Karsenti JM, Venti H, Fuzibet JG, Rosenthal E, Ceppi C, Quaranta M, Krivitsky JA, Bentata M, Bouchaud O, Honore P, Sereni D, Lascoux C, Delgado J, Rouzioux C, Burgard M, Boufassa L, Peynet J, Ferreros I, Hurtado I, Jarrín I, González C, Caro AM, Sanviens A, Clotet B, Tor J, del Romero J, Raposo P, Rodríguez C, García S, Garcia de Olalla P, Cayla J, Alastrue I, Belda J, Trullen P, Fernández E, Santos C, Tasa T, Zafra T, Guerrero R, Marco A, Quintana M, Ruiz I, Nuñez R, Pérez R, Castilla J, Guevara M, de Mendoza C, Zahonero N, Antoniadou A, Chrysos G, Daikos G, Gargalianos-Kakolyris P, Gogos HA, Katsarou O, Kordossis T, Lazanas M, Nikolaidis P, Panos G, Paparizos V, Paraskevis D, Sambatakou H, Skoutelis A, Pantazis N, Bakoyannis G, Gioukari V, Antoniadou A, Papadopoulos A, Petrikkos G, Chrysos G, Paraskeva D, Hatziastros P, Daikos G, Psichogiou M, Xylomenos G, Gogos HA, Maragos MN, Katsarou O, Kouramba A, Ioannidou P, Kordossis T, Kontos A, Lazanas M, Chini M, Tsogas N, Kolaras P, Metallidis S, Haratsis G, Leuow K, Kourkounti S, Sambatakou H, Mariolis I, Skoutelis A, Papastamopoulos V, Baraboutis I.

Abstract

OBJECTIVE:

To compare regimens consisting of either efavirenz or nevirapine and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV-infected, antiretroviral-naive, and AIDS-free individuals with respect to clinical, immunologic, and virologic outcomes.

DESIGN:

Prospective studies of HIV-infected individuals in Europe and the US included in the HIV-CAUSAL Collaboration.

METHODS:

Antiretroviral therapy-naive and AIDS-free individuals were followed from the time they started an NRTI, efavirenz or nevirapine, classified as following one or both types of regimens at baseline, and censored when they started an ineligible drug or at 6 months if their regimen was not yet complete. We estimated the 'intention-to-treat' effect for nevirapine versus efavirenz regimens on clinical, immunologic, and virologic outcomes. Our models included baseline covariates and adjusted for potential bias introduced by censoring via inverse probability weighting.

RESULTS:

A total of 15 336 individuals initiated an efavirenz regimen (274 deaths, 774 AIDS-defining illnesses) and 8129 individuals initiated a nevirapine regimen (203 deaths, 441 AIDS-defining illnesses). The intention-to-treat hazard ratios [95% confidence interval (CI)] for nevirapine versus efavirenz regimens were 1.59 (1.27, 1.98) for death and 1.28 (1.09, 1.50) for AIDS-defining illness. Individuals on nevirapine regimens experienced a smaller 12-month increase in CD4 cell count by 11.49 cells/μl and were 52% more likely to have virologic failure at 12 months as those on efavirenz regimens.

CONCLUSIONS:

Our intention-to-treat estimates are consistent with a lower mortality, a lower incidence of AIDS-defining illness, a larger 12-month increase in CD4 cell count, and a smaller risk of virologic failure at 12 months for efavirenz compared with nevirapine.

PMID:
22546987
PMCID:
PMC3647467
DOI:
10.1097/QAD.0b013e328354f497
[Indexed for MEDLINE]
Free PMC Article

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