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Virulence. 2012 May 1;3(3):329-38. doi: 10.4161/viru.20142. Epub 2012 May 1.

Mouse models for the study of fungal pneumonia: a collection of detailed experimental protocols for the study of Coccidioides, Cryptococcus, Fusarium, Histoplasma and combined infection due to Aspergillus-Rhizopus.

Author information

1
Division of Infectious Diseases, Harvard Medical School and Massachusetts General Hospital Boston, MA, USA.

Abstract

Mouse models have facilitated the study of fungal pneumonia. In this report, we present the working protocols of groups that are working on the following pathogens: Aspergillus, Coccidioides, Cryptococcus, Fusarium, Histoplasma and Rhizopus. We describe the experimental procedures and the detailed methods that have been followed in the experienced laboratories to study pulmonary fungal infection; we also discuss the anticipated results and technical notes, and provide the practical advices that will help the users of these models.

PMID:
22546902
PMCID:
PMC3442846
DOI:
10.4161/viru.20142
[Indexed for MEDLINE]
Free PMC Article

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