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Med Hypotheses. 2012 Jul;79(1):113-7. doi: 10.1016/j.mehy.2012.03.036. Epub 2012 Apr 29.

Allocentric lock in anorexia nervosa: new evidences from neuroimaging studies.

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Applied Technology for Neuro-Psychology Lab, Istituto Auxologico Italiano, Milan, Italy.


Individuals with anorexia nervosa (AN) have a disturbance in the way in which their body is experienced and tend to evaluate negatively their own body and body parts. It is controversial whether these symptoms are secondary to dysfunctions in the neuronal processes related to appetite and emotional regulation or reflect a primary disturbance in the way the body is experienced and remembered. According to the "Allocentric Lock Hypothesis--ALH" ( individuals with AN may be locked to an allocentric (observer view) negative memory of the body that is no more updated by contrasting egocentric representations driven by perception. Recent neuroimaging studies are showing several structural and functional alterations in frame- and memory-related body-image-processing brain circuits that may support ALH.

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