Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2012 Jun 1;22(11):3751-3. doi: 10.1016/j.bmcl.2012.04.031. Epub 2012 Apr 13.

Wake promoting agents: search for next generation modafinil, lessons learned: part III.

Author information

1
Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.

Abstract

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).

PMID:
22546675
DOI:
10.1016/j.bmcl.2012.04.031
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center