Format

Send to

Choose Destination
J Exp Clin Cancer Res. 2012 Apr 30;31:38. doi: 10.1186/1756-9966-31-38.

Circulating microRNAs in cancer: origin, function and application.

Author information

1
Laboratory Diagnosis Center, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level. The dysregulation of miRNAs has been linked to a series of diseases, including various types of cancer. Since their discovery in the circulation of cancer patients, there has been a steady increase in the study of circulating miRNAs as stable, non-invasive biomarkers. However, the origin and function of circulating miRNAs has not been systematically elucidated. In this review, we summarize the discovery of circulating miRNAs and their potential as biomarkers. We further emphasize their possible origin and function. Finally, we discuss the application and existing questions surrounding circulating miRNAs in cancer diagnostics. Although several challenges remain to be concerned, circulating miRNAs could be useful, non-invasive biomarkers for cancer diagnosis.

PMID:
22546315
PMCID:
PMC3431991
DOI:
10.1186/1756-9966-31-38
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center