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Bioorg Med Chem. 2012 Jun 1;20(11):3378-95. doi: 10.1016/j.bmc.2012.03.069. Epub 2012 Apr 13.

Recent developments and biological activities of thiazolidinone derivatives: a review.

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1
Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470 003, MP, India.

Abstract

Thiazolidinone is considered as a biologically important active scaffold that possesses almost all types of biological activities. Successful introduction of ralitoline as a potent anti-convulsant, etozoline as a antihypertensive, pioglitazone as a hypoglycemic agent and thiazolidomycin activity against streptomyces species proved potential of thiazolidinone moiety. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. This review is complementary to earlier reviews and aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011. Data are presented for active compounds, some of which have passed the preclinical testing stage.

PMID:
22546204
DOI:
10.1016/j.bmc.2012.03.069
[Indexed for MEDLINE]

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