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Genome Biol. 2012;13(4):244.

Genetic architecture of body size in mammals.

Author information

1
Faculty of Land and Environment, University of Melbourne, Parkville, Victoria 3010, Australia. kathryn.kemper@dpi.vic.gov.au

Abstract

Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.

PMID:
22546202
PMCID:
PMC3446298
DOI:
10.1186/gb4016
[Indexed for MEDLINE]
Free PMC Article
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