Send to

Choose Destination
See comment in PubMed Commons below
Tetrahedron Lett. 2012 May 23;53(21):2592-2594. Epub 2012 Mar 24.

Hydrazine-mediated cyclization of Ugi products to synthesize novel 3-hydroxypyrazoles.

Author information

Department of Pharmacology and Toxicology, College of Pharmacy, BIO5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA.


This report discloses a novel concise synthesis of a series of 3-hydroxypyrazoles 5 via a tandem Ugi/debenzylation /hydrazine-mediated cyclization sequence. Herein, n-butyl isocyanide 4b was utilized as an alternative to classical convertible isocyanides enabling high yielding hydrazine-mediated cyclization. Taken together, a novel class of 3-hydroxypyrazoles 5a-5i was synthesized with potential to be of interest in future library enrichment strategies.

PubMed Commons home

PubMed Commons


    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center