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Protein Cell. 2012 May;3(5):372-82. doi: 10.1007/s13238-012-2021-x. Epub 2012 Apr 28.

The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.

Author information

1
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

Abstract

Herpes simplex virus type 1 (HSV-1) is a common human pathogen causing cold sores and even more serious diseases. It can establish a latent stage in sensory ganglia after primary epithelial infections, and reactivate in response to stress or sunlight. Previous studies have demonstrated that viral immediate-early protein ICP0 plays a key role in regulating the balance between lytic and latent infection. Recently, It has been determined that promyelocytic leukemia (PML) nuclear bodies (NBs), small nuclear sub-structures, contribute to the repression of HSV-1 infection in the absence of functional ICP0. In this review, we discuss the fundamentals of the interaction between ICP0 and PML NBs, suggesting a potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1.

PMID:
22544561
PMCID:
PMC4875467
DOI:
10.1007/s13238-012-2021-x
[Indexed for MEDLINE]
Free PMC Article

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