Format

Send to

Choose Destination
Nat Genet. 2012 Apr 29;44(6):670-5. doi: 10.1038/ng.2261.

Meta-analysis identifies six new susceptibility loci for atrial fibrillation.

Author information

1
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA. pellinor@partners.org

Abstract

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 × 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.

PMID:
22544366
PMCID:
PMC3366038
DOI:
10.1038/ng.2261
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center