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Nat Neurosci. 2012 Jun;15(6):813-5. doi: 10.1038/nn.3099.

Calbindin controls release probability in ventral tegmental area dopamine neurons.

Author information

1
Department of Biochemistry, Weill Cornell Medical College, New York, NY, USA. taryan@med.cornell.edu

Abstract

Relatively little is known about the molecular control of midbrain dopamine release. Using high-fidelity imaging of pHluorin-tagged vesicular monoamine transporter 2 in dopamine neurons, we found that exocytosis was more loosely coupled to calcium entry than in fast synapses. In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons.

PMID:
22544312
PMCID:
PMC3703651
DOI:
10.1038/nn.3099
[Indexed for MEDLINE]
Free PMC Article

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