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Pediatr Infect Dis J. 2012 Jul;31(7):729-31. doi: 10.1097/INF.0b013e3182587796.

Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.

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1
Department of Paediatrics, University of Nairobi, Nairobi, Kenya. dalton@africaonline.co.ke

Abstract

Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.

PMID:
22544051
PMCID:
PMC3756892
DOI:
10.1097/INF.0b013e3182587796
[Indexed for MEDLINE]
Free PMC Article
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