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Exp Cell Res. 2012 Jul 1;318(11):1269-77. doi: 10.1016/j.yexcr.2012.04.005. Epub 2012 Apr 17.

The 'complexities' of life and death: death receptor signalling platforms.

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MRC Toxicology Unit, University of Leicester, Leicester, UK.


Cell death is critical to the normal functioning of multi-cellular organisms, playing a central role in development, immunity, inflammation, and cancer progression. Two cell death mechanisms, apoptosis and necroptosis, are dependent on the formation of distinct multi-protein complexes including the DISC, Apoptosome, Piddosome and Necrosome following the induction of cell death by specific stimuli. The role of several of these key multi-protein signalling platforms, namely the DISC, TNFR1 complex I/II, the Necrosome and Ripoptosome, in mediating these pathways will be discussed, as well as the open questions and potential therapeutic benefits of understanding their underlying mechanisms.

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