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Vet Parasitol. 2012 Sep 10;188(3-4):261-7. doi: 10.1016/j.vetpar.2012.03.055. Epub 2012 Apr 4.

Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine.

Author information

1
Veterinary Clinical Centre, The University of Melbourne, 250 Princes Hwy, Werribee, Victoria 3030, Australia. cesarj@pgrad.unimelb.edu.au

Abstract

Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n=137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200 μg of each of TSOL16 and TSOL18, plus 5mg Quil-A. Necropsies were performed 7 months after the animals were distributed to the farmers. Vaccination reduced 99.7% and 99.9% (p<0.01) the total number of cysts and the number of viable cysts, respectively. Immunization with the TSOL16-TSOL18 vaccines has the potential to control T. solium transmission in areas where the disease is endemic, reducing the source for tapeworm infections in humans.

PMID:
22541797
PMCID:
PMC3420019
DOI:
10.1016/j.vetpar.2012.03.055
[Indexed for MEDLINE]
Free PMC Article

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