Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Cell. 2012 Apr 27;46(2):115-24. doi: 10.1016/j.molcel.2012.04.009.

R loops: from transcription byproducts to threats to genome stability.

Author information

1
CABIMER, Universidad de Sevilla-CSIC, Av. Américo Vespucio s/n, 41092 Sevilla, Spain. aguilo@us.es

Abstract

RNA:DNA hybrid structures known as R loops were thought to be rare byproducts of transcription. In the last decade, however, accumulating evidence has pointed to a new view in which R loops form more frequently, impacting transcription and threatening genome integrity as a source of chromosome fragility and a potential cause of disease. Not surprisingly, cells have evolved mechanisms to prevent cotranscriptional R loop formation. Here we discuss the factors and cellular processes that control R loop formation and the mechanisms by which R loops may influence gene expression and the integrity of the genome.

PMID:
22541554
DOI:
10.1016/j.molcel.2012.04.009
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center