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Trends Biotechnol. 2012 Jul;30(7):377-85. doi: 10.1016/j.tibtech.2012.03.004. Epub 2012 Apr 26.

Systems biotechnology of animal cells: the road to prediction.

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Instituto de Tecnologia Química e Biológica-Universidade Nova de Lisboa, 2780-901 Oeiras, Portugal.


A central concern of biopharmaceutical R&D is the production of sufficient quantities of recombinant products from manufacturing processes based on animal cell culture. The way in which bioprocess researchers have addressed this question experienced a tremendous shift over the years, progressing from almost empirical to more rational approaches. A step further is the application of systems biotechnology: recent technological advances for large-scale cell state characterization and creative methods for host cell modeling are becoming crucial for next-generation bioprocess optimization. Here we provide an overview of the main trends towards this goal, with a focus on metabolic models as central scaffolds for data integration and prediction of bioprocess outcomes.

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