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Br J Dermatol. 2012 Sep;167(3):506-13. doi: 10.1111/j.1365-2133.2012.11026.x. Epub 2012 Jul 19.

Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse.

Author information

1
BioCis Pharma Ltd, Itainen Pitkakatu 4 B, FI-20520 Turku, Finland. jarmo.laihia@biocis.com

Abstract

BACKGROUND:

cis-Urocanic acid (cis-UCA) is an endogenous immunosuppressive molecule of the epidermis.

OBJECTIVES:

 We investigated the effects of topical cis-UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation.

METHODS:

Acute skin irritation was induced by applying dimethyl sulphoxide (DMSO) on the earlobe of CD-1 mice. Topical cis-UCA, hydrocortisone (1%) or tacrolimus (0·1%) were applied 10 min later. In another model, subacute inflammation was provoked and maintained by three applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the ears of NMRI mice on days 1, 2 and 4. The test products were applied topically twice a day during 6 days.

RESULTS:

In the acute DMSO model, cis-UCA creams suppressed ear swelling at 1 h significantly more efficiently than hydrocortisone (P < 0·01) and tacrolimus (P < 0·001). Ear swelling was significantly inhibited by cis-UCA (P < 0·001) in the subacute TPA model as well. The 5% cream also decreased erythema, whereas tacrolimus enhanced skin reddening. Treatments with cis-UCA did not affect TPA-induced infiltration of neutrophils to the skin. In contrast to hydrocortisone, cis-UCA did not reduce epidermal thickness.

CONCLUSIONS:

The results suggest that cis-UCA - unlike hydrocortisone and tacrolimus - is efficient in both acute and subacute skin inflammation, attenuating skin oedema and erythema. Topical drug therapy with cis-UCA may provide a safe and effective drug treatment modality in inflammatory skin disorders.

[Indexed for MEDLINE]

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