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Toxicon. 2012 Sep 1;60(3):254-64. doi: 10.1016/j.toxicon.2012.04.336. Epub 2012 Apr 14.

Receptor-targeting mechanisms of pain-causing toxins: How ow?

Author information

1
Department of Physiology, University of California, San Francisco, CA 94158-2517, USA. christopher.bohlen@ucsf.edu

Abstract

Venoms often target vital processes to cause paralysis or death, but many types of venom also elicit notoriously intense pain. While these pain-producing effects can result as a byproduct of generalized tissue trauma, there are now multiple examples of venom-derived toxins that target somatosensory nerve terminals in order to activate nociceptive (pain-sensing) neural pathways. Intriguingly, investigation of the venom components that are responsible for evoking pain has revealed novel roles and/or configurations of well-studied toxin motifs. This review serves to highlight pain-producing toxins that target the capsaicin receptor, TRPV1, or members of the acid-sensing ion channel family, and to discuss the utility of venom-derived multivalent and multimeric complexes.

PMID:
22538196
PMCID:
PMC3383939
DOI:
10.1016/j.toxicon.2012.04.336
[Indexed for MEDLINE]
Free PMC Article
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