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FEBS Lett. 1990 Nov 12;274(1-2):151-5.

All-D-magainin: chirality, antimicrobial activity and proteolytic resistance.

Author information

1
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot, Israel.

Abstract

All-D-magainin-2 was synthesized to corroborate experimentally the notion that the biological function of a surface-active peptide stems primarily from its unique amphiphilic alpha-helical structure. Indeed, the peptide exhibited antibacterial potency nearly identical to that of the all-L-enantiomer. Being highly resistant to proteolysis and non-hemolytic all-D-magainin might have considerable therapeutic importance.

PMID:
2253768
DOI:
10.1016/0014-5793(90)81351-n
[Indexed for MEDLINE]
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