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FEBS Lett. 1990 Nov 12;274(1-2):107-10.

Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol.

Author information

1
Department of Biochemistry, University of London, King's College, UK.

Abstract

The anticancer drug tamoxifen when introduced into phospholipid liposomes during their preparation inhibited Fe(III)-ascorbate induced lipid peroxidation to a greater extent than similarly introduced cholesterol. Ergosterol was equipotent with tamoxifen, but much less effective than 4-hydroxytamoxifen. Possible mechanisms underlying these effects are discussed in relation to structural mimicry of the sterols by these triphenylethylene drugs as membrane stabilizers against lipid peroxidation.

PMID:
2253763
DOI:
10.1016/0014-5793(90)81341-k
[Indexed for MEDLINE]
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