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Farmakol Toksikol. 1990 Sep-Oct;53(5):37-9.

[A comparative study of the toxic and therapeutic effects of digoxin and its immobilized form].

[Article in Russian]


It was shown on different species of laboratory animals (frogs, mice, rats) that digoxin immobilized on the copolymer was 8-15 times less toxic that its usual preparation. In this case glycoside fixed on the copolymer preserves completely its specific cardiotonic effect, i.e., possesses a wider range of the therapeutic action.

[Indexed for MEDLINE]

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