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Acta Paediatr. 2012 Sep;101(9):896-9. doi: 10.1111/j.1651-2227.2012.02715.x. Epub 2012 May 16.

Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature.

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1
Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Denmark. ellen.morling.taaning@rh.regionh.dk

Abstract

Foetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia caused by maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding caused by maternal anti-HPA-3a alloantibodies and mild neutropenia caused by maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions.

CONCLUSION:

This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays.

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