Format

Send to

Choose Destination
Org Lett. 2012 May 4;14(9):2362-5. doi: 10.1021/ol300781s. Epub 2012 Apr 26.

Mn-promoted aerobic oxidative C-C bond cleavage of aldehydes with dioxygen activation: a simple synthetic approach to formamides.

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.

Abstract

A novel Mn-promoted aerobic oxidative C-C bond cleavage of aldehydes with dioxygen activation has been developed. The usage of molecular oxygen (1 atm) as oxidant, reactant, and an initiator to trigger this transformation makes this transformation very green and practical. A plausible radical process is proposed on the basis of mechanistic studies. Furthermore, this method provides a practical, neutral, and mild synthetic approach to formamides, which are important units in biologically active molecules.

PMID:
22536981
DOI:
10.1021/ol300781s
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center