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Clin Microbiol Infect. 2012 Aug;18(8):E299-304. doi: 10.1111/j.1469-0691.2012.03847.x. Epub 2012 Apr 27.

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

Author information

1
Institute of Clinical Infectious Diseases, Catholic University of S. Heart, Rome, Italy. manuela76@inwind.it

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.

PMID:
22536753
PMCID:
PMC6029625
DOI:
10.1111/j.1469-0691.2012.03847.x
[Indexed for MEDLINE]
Free PMC Article

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