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J Allergy (Cairo). 2012;2012:106069. doi: 10.1155/2012/106069. Epub 2012 Mar 22.

A randomised, double-blind pilot study of enzyme-potentiated desensitisation for prophylaxis of large local reactions to mosquito bites.

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1
Royal London Hospital for Integrated Medicine, University College London Hospital NHS Foundation Trust, 60 Great Ormond Street, London WC1N 3HR, UK.

Abstract

PRIMARY OBJECTIVE:

To test the hypothesis that two injections of enzyme-potentiated mosquito antigen significantly reduce the size of experimental mosquito bites in participants with LLR-MB.

DESIGN:

Randomised, double-blind, placebo-controlled, parallel group comparison over 3 months.

SETTING:

Hospital outpatient clinic.

PARTICIPANTS:

Fifty adult participants of both sexes.

INTERVENTIONS:

Two injections of mosquito antigen or matching placebo, 6 weeks apart.

MAIN OUTCOME MEASURES:

Early (1 hour) and late (24 hours) mean square root of erythema area (SREA) following controlled mosquito bite with the second bite given at least 6 weeks following the final injection.

RESULTS:

At 1 hour, mean SREA was slightly higher in the EPD group compared to placebo after adjusting for baseline values (0.46, 95% CI -6.11 to 7.03), but this was not statistically significant (P = 0.89, ANCOVA analysis); neither were the results at 24 hours (-2.58, 95% CI -11.73 to 6.57) (P = 0.57). The proportion of participants experiencing a decrease in wheal size at 1 or 24 hours was similar between groups.

CONCLUSIONS:

EPD was not demonstrated to be effective for immediate or delayed LLR-MB. Methodological problems included a high variability in LLR-MB between subjects, suggesting that a crossover design should be used in future.

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