Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Neuroinform. 2012 Apr 24;6:13. doi: 10.3389/fninf.2012.00013. eCollection 2012.

The importance of combining MRI and large-scale digital histology in neuroimaging studies of brain connectivity and disease.

Author information

  • 1Department of Radiology and Biomedical Imaging, The Brain Observatory, University of California, San Diego CA, USA.

Abstract

One of the major issues hindering a comprehensive connectivity model for the human brain is the difficulty in linking Magnetic Resonance Imaging (MRI) measurements to anatomical evidence produced by histological methods. In vivo and postmortem neuroimaging methodologies are still largely incompatible in terms of sample size, scale, and resolution. To help bridge the hiatus between different approaches we have established a program that characterizes the brain of individual subjects, combining MRI with postmortem neuroanatomy. The direct correlation of MRI and histological features is possible, because registered images from different modalities represent the same regions in the same brain. Comparisons are also facilitated by large-scale, digital microscopy techniques that afford images of the whole-brain sections at cellular resolution. The goal is to create a neuroimaging catalog representative of discrete age groups and specific neurological conditions. Individually, the datasets allow for investigating the relationship between different modalities; combined, they provide sufficient predictive power to inform analyzes and interpretations made in the context of non-invasive studies of brain connectivity and disease.

KEYWORDS:

DTI; MRI; brain; connectivity; fibers; histology; human; pathology

PMID:
22536182
PMCID:
PMC3334523
DOI:
10.3389/fninf.2012.00013
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center