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J Biomed Biotechnol. 2012;2012:876458. doi: 10.1155/2012/876458. Epub 2012 Mar 28.

Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts.

Author information

1
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia. khalijah@um.edu.my

Abstract

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.

PMID:
22536026
PMCID:
PMC3321480
DOI:
10.1155/2012/876458
[Indexed for MEDLINE]
Free PMC Article

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