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Cold Spring Harb Perspect Biol. 2012 Jun 1;4(6). pii: a007930. doi: 10.1101/cshperspect.a007930.

Wnt/Wingless signaling in Drosophila.

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1
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.

Abstract

The Wingless (Wg) pathway represents one of the best-characterized intercellular signaling networks. Studies performed in Drosophila over the last 30 years have contributed to our understanding of the role of Wg signaling in the regulation of tissue growth, polarity, and patterning. These studies have revealed mechanisms conserved in the vertebrate Wnt pathways and illustrate the elegance of using the Drosophila model to understand evolutionarily conserved modes of gene regulation. In this article, we describe the function of Wg signaling in patterning the Drosophila embryonic epidermis and wing imaginal disc. As well, we present an overview of the establishment of the Wg morphogen gradient and discuss the differential modes of Wg-regulated gene expression.

PMID:
22535229
PMCID:
PMC3367557
DOI:
10.1101/cshperspect.a007930
[Indexed for MEDLINE]
Free PMC Article
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