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Vasc Endovascular Surg. 2012 May;46(4):300-9. doi: 10.1177/1538574412443315. Epub 2012 Apr 25.

Gene expression profiling in acute Stanford type B aortic dissection.

Author information

1
Department of vascular surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Abstract

OBJECTIVE:

To compare the gene expression profiles of the aorta specimens between patients with Stanford type B aortic dissection (AD) and controls.

MATERIALS AND METHODS:

Samples of descending aorta were collected from patients with type B AD (n = 12) and from multiorgan donors as controls (n = 12). Phalanx whole genome microarray was used to analyze differential gene expression.

RESULTS:

Of the 6375 probes validated, 623 genes were found to be differentially expressed between patients with type B AD and controls (fold change ≥2). Gene ontology analysis identified significantly enriched gene groups pertaining to cell-cell adhesion, extracellular matrix, cell-matrix adhesion, cytoskeleton, immune and inflammatory response, and apoptosis.

CONCLUSION:

Genes encoding components related to integrity and strength of the aortic wall were downregulated, whereas those related to inflammatory response were upregulated in type B AD. The altered patterns of gene expression indicate preexisting structural defects that are probably a consequence of insufficient remodeling of the aortic wall.

PMID:
22534613
DOI:
10.1177/1538574412443315
[Indexed for MEDLINE]

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