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Eur Arch Otorhinolaryngol. 2012 Sep;269(9):2087-90. doi: 10.1007/s00405-012-1971-1. Epub 2012 Apr 25.

Zinc sulfate therapy of vocal process granuloma.

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ENT Department, GongLi Hospital, Pudong new area, Shanghai 200135, China.


Vocal process granuloma is a benign lesion that occurs on the arytenoid cartilage. It tends to recur locally, and there is a great diversity of methods to treat it. Here, we reviewed the effects of zinc sulfate therapy program in 16 patients with vocal process granulomas. Eleven patients had a history of trauma or laryngeal intubation and five patients had unknown origin. Eleven had recurrence after one to three failed surgeries, and the others had no prior treatment. Symptoms included hoarseness, sore throat, lump sensation in the throat and cough that apparently improved. The granulomas did not recur for at least 1 year. No complications occurred. For vocal process granuloma, zinc sulfate therapy is good either as an initial or compensatory treatment.

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