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Nat Rev Immunol. 2012 Apr 25;12(5):367-82. doi: 10.1038/nri3210.

Interferon-inducible effector mechanisms in cell-autonomous immunity.

Author information

1
Section of Microbial Pathogenesis, Boyer Centre for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA. john.macmicking@yale.edu

Abstract

Interferons (IFNs) induce the expression of hundreds of genes as part of an elaborate antimicrobial programme designed to combat infection in all nucleated cells - a process termed cell-autonomous immunity. As described in this Review, recent genomic and subgenomic analyses have begun to assign functional properties to novel IFN-inducible effector proteins that restrict bacteria, protozoa and viruses in different subcellular compartments and at different stages of the pathogen life cycle. Several newly described host defence factors also participate in canonical oxidative and autophagic pathways by spatially coordinating their activities to enhance microbial killing. Together, these IFN-induced effector networks help to confer vertebrate host resistance to a vast and complex microbial world.

PMID:
22531325
PMCID:
PMC4150610
DOI:
10.1038/nri3210
[Indexed for MEDLINE]
Free PMC Article

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