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Bioinformatics. 2012 Jun 15;28(12):1645-6. doi: 10.1093/bioinformatics/bts197. Epub 2012 Apr 23.

Tachyon search speeds up retrieval of similar sequences by several orders of magnitude.

Author information

1
Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), 30 Biopolis Street, #07-01, Matrix, 138671, Singapore.

Abstract

The usage of current sequence search tools becomes increasingly slower as databases of protein sequences continue to grow exponentially. Tachyon, a new algorithm that identifies closely related protein sequences ~200 times faster than standard BLAST, circumvents this limitation with a reduced database and oligopeptide matching heuristic.

AVAILABILITY AND IMPLEMENTATION:

The tool is publicly accessible as a webserver at http://tachyon.bii.a-star.edu.sg and can also be accessed programmatically through SOAP.

PMID:
22531216
PMCID:
PMC3371831
DOI:
10.1093/bioinformatics/bts197
[Indexed for MEDLINE]
Free PMC Article

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