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Antioxid Redox Signal. 2012 Oct 1;17(7):934-6. doi: 10.1089/ars.2012.4669. Epub 2012 Jun 6.

S-nitrosation: current concepts and new developments.

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1
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, USA.

Abstract

The S-nitrosation (also referred to as S-nitrosylation) of cysteine residues is an important post-translational protein modification that regulates protein function and cell signaling. The original research articles and reviews in this Forum cover important concepts in protein S-nitrosation and identify key developments and opportunities for progress in this area. Defining the mechanisms by which S-nitrosothiols (RSNOs) may be formed and decomposed in cells and tissues, the integration of the biological chemistry associated with nitric oxide (NO) and other derivatives such as nitrite, and the development of new methodologies merging proteomics and direct quantitation are all key issues that we believe would require detailed attention.

PMID:
22530975
PMCID:
PMC3411337
DOI:
10.1089/ars.2012.4669
[Indexed for MEDLINE]
Free PMC Article
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