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Neurol Res Int. 2012;2012:561494. doi: 10.1155/2012/561494. Epub 2012 Mar 11.

The role of cytokines and inflammatory cells in perinatal brain injury.

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1
Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195-6320, USA.

Abstract

Perinatal brain injury frequently complicates preterm birth and leads to significant long-term morbidity. Cytokines and inflammatory cells are mediators in the common pathways associated with perinatal brain injury induced by a variety of insults, such as hypoxic-ischemic injury, reperfusion injury, toxin-mediated injury, and infection. This paper examines our current knowledge regarding cytokine-related perinatal brain injury and specifically discusses strategies for attenuating cytokine-mediated brain damage.

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