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J Biomed Biotechnol. 2012;2012:412486. doi: 10.1155/2012/412486. Epub 2012 Mar 24.

SPECT molecular imaging in Parkinson's disease.

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1
Department of Nuclear Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.

Abstract

Parkinson's disease (PD) is a common disorder, and the diagnosis of Parkinson's disease is clinical and relies on the presence of characteristic motor symptoms. The accuracy of the clinical diagnosis of PD is still limited. Functional neuroimaging using SPECT technique is helpful in patients with first signs of parkinsonism. The changes detected may reflect the disease process itself and/or compensatory responses to the disease, or they may arise in association with disease- and/or treatment-related complications. This paper addresses the value of SPECT in early differential diagnosis of PD and its potential as a sensitive tool to assess the pathophysiology and progression, as well as the therapeutic efficacy of PD.

PMID:
22529704
PMCID:
PMC3321451
DOI:
10.1155/2012/412486
[Indexed for MEDLINE]
Free PMC Article
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